Being diagnosed with haematologic malignancy actually happens either because the patient presents with certain symptoms or – as is becoming increasingly common – there are incidental findings during routine blood screening on modern haematology analysers. This white paper aims to describe how parameters of a complete blood count may reveal significant abnormalities and improve the incidental findings of suspected haematologic samples early on.
This case study explains how the same lymphocytes react in two different complementary methods: fluorescence flow cytometry in the WPC channel of the XN-Series haematology analyser and multicolour immunophenotyping using the XF-1600 analyser. The haematology analyser detected a lymphocytosis and a suspect flag for ‘Abnormal Lympho?’. Subsequently, clinical flow cytometry was performed and the markers confirmed the diagnosis of a B-CLL in this patient.
A patient case showing early detection of latent iron deficiency, that would not have been detected in a normal routine blood count or blood smear is described. A low RET-He (reticulocyte haemoglobin equivalent) value triggered a confirmatory test and lead to prompt treatment of the patient.